Originally published 1915. This reprints the edition of 1969. When originally published this volume was the first history of English schools before the Reformation, reckoned from the accession of Edward VI.

Long DNA palindromes pose a threat to genome stability. This instability is primarily mediated by slippage on the lagging strand of the replication fork between short directly repeated sequences close to the ends of the palindrome. The role of the palindrome is likely to be the juxtaposition of the directly repeated sequences by intrastrand base‐pairing. This intra‐strand base‐pairing, if present on both strands, results in a cruciform structure. In bacteria, cruciform structures have proved difficult to detect in vivo, suggesting that (...) if they form, they are either not replicated or are destroyed. SbcCD, a recently discovered exonuclease of Escherichia coli, is responsible for preventing the replication of long palindromes. These observations lead to the proposal that cells may have evolved a post‐replicative mechanism for the elimination and/or repair of large DNA secondary structures. (shrink)

T. Macci Plauti Menaechmi, editio altera a F. Schoell recognita . 5 M. 60. The Menaechmi of Plautus, edited on the basis of Brix's edition, by Harold North Fowler, Ph. D.

Frege’s Basic Law V and its successor, Boolos’s New V, are axioms postulating abstraction operators: mappings from the power set of the domain into the domain. Basic Law V proved inconsistent. New V, however, naturally interprets large parts of second-order ZFC via a construction discovered by Boolos in 1989. This paper situates these classic findings about abstraction operators within the general theory of F-algebras and coalgebras. In particular, we show how Boolos’s construction amounts to identifying an initial F-algebra in a (...) certain category, we identify a natural coalgebraic dual to Boolos’s axiom which naturally interprets large parts of Aczel’s non-well-founded set theory via the construction of a certain terminal F-coalgebra, and we suggest a coalgebraic way forward for an abstraction-theoretic axiomatization of the real numbers. (shrink)

Soil is fragile and nonrenewable but the most basic of natural resources. It has a capacity to tolerate continuous use but only with proper management. Improper soil management and indiscriminate use of chemicals have contributed to some severe global environmental issues, e.g., volatilization losses and contamination of natural waters by sediments and agricultural fertilizers and pesticides. The increasing substitution of energy for labor and other cultural inputs in agriculture is another issue. Fertilizers and chemicals account for about 25% of the (...) production energy investment in agriculture. An additional 60% is accounted for by machinery, gasoline, electricity, and power-related inputs. Fertilizer additions to cropland are not utilized fully and significant amounts, depending on conditions, are either lost in surface runoff or leached into the ground water. The annual discharge of dissolved solids from agricultural lands to the waterways in the USA is substantial. The increasing use of herbicides in agriculture is a threat to the quality of surface and ground water, although this threat is dependent upon both the chemistry of the compound and the ecosystem in which it is used. Especially within the Third World, development of an environmental ethic and environmental laws have not kept pace with the increase in pesticide use. Above all is the severe and global problem of soil degradation currently occurring at the rate of five to seven million hectares per year. The policy and moral aspects of these issues are discussed. (shrink)

A review and discussion of C. A. Hooker, J. J. Leach, and E. F. McClennen's edited volumes, Foundations and Applications of Decision Theory. Volume 1: Theoretical Foundations. Volume 2: Epistemic and Social Applications.

Материалы сборника предназначены для специалистов.

In this paper, it is explained that a dialogical approach to complex argumentation can be fruitful for solving two important problems concerning the analysis of the argumentation structure. First, such an approach makes it possible to clarify the distinction between coordinative and multiple argumentation structures, and to identify clues in the presentation for each of these structures. Second, a dialogical approach can provide a basis for dealing more adequately with refutations of counterarguments.

Dialektika mifa -- Raboty 1916-1988 godov -- Istorii︠a︡ filosofii kak shkola mysli.

Objectives: to assess physicians’ and patients’ views in Saudi Arabia towards involving the patient versus the family in the process of diagnosis disclosure and decision-making, and to compare them with views from the USA and Japan.Design: A self-completion questionnaire was translated to Arabic and validated.Participants: Physicians from different specialties and ranks and patients in a hospital or attending outpatient clinics from 6 different regions in KSA.Results: In the case of a patient with incurable cancer, 67% of doctors and 51% of (...) patients indicated that they would inform the patient in preference to the family of the diagnosis . Assuming the family already knew, 56% of doctors and 49% of patients would tell the patient even if family objected . However, in the case of HIV infection, 59% of physicians and 81% of patients would inform the family about HIV status without the patient’s consent . With regards to withholding ventilatory support, about 50% of doctors and over 60% of patients supported the use of mechanical ventilation in a patient with advanced cancer, regardless of the wishes of the patient or the family. Finally, the majority of doctors and patients were against assisted suicide.Conclusions: Although there was more recognition for a patient’s autonomy amongst physicians, most patients preferred a family centred model of care. Views towards information disclosure were midway between those of the USA and Japan. Distinctively, however, decisions regarding life prolonging therapy and assisted suicide were not influenced to a great extent by wishes of the patient or family, but more likely by religious beliefs. (shrink)

From the editors of Voprosy filosofii: December 23, 1972, marked the seventieth birthday of A. F. Shishkin, leading Soviet philosopher, major specialist in the field of ethics, one of the oldest and at the same time most active members of the editorial board of our journal. The editors sincerely congratulate Aleksandr Fedorovich on this anniversary and wish him further successes in his work, firm health, and long years of life.

Evolutionary developmental biology (evo-devo) has undergone dramatic transformations since its emergence as a distinct discipline. This paper aims to highlight the scope, power, and future promise of evo-devo to transform and unify diverse aspects of biology. We articulate key questions at the core of eleven biological disciplines—from Evolution, Development, Paleontology, and Neurobiology to Cellular and Molecular Biology, Quantitative Genetics, Human Diseases, Ecology, Agriculture and Science Education, and lastly, Evolutionary Developmental Biology itself—and discuss why evo-devo is uniquely situated to substantially improve (...) our ability to find meaningful answers to these fundamental questions. We posit that the tools, concepts, and ways of thinking developed by evo-devo have profound potential to advance, integrate, and unify biological sciences as well as inform policy decisions and illuminate science education. We look to the next generation of evolutionary developmental biologists to help shape this process as we confront the scientific challenges of the 21st century. (shrink)

The editors planned the appearance of this article to coincide with the seventy-fifth birthday of the author, which was to have been marked in December. The issue had already been approved for publication when the sad news came of the sudden death of Aleksandr Fedorovich Shishkin, prominent Soviet philosopher, member of the editorial board of our journal, a remarkable human being, our comrade and friend.

The recurrence of horse-imagery in Alcman's Partheneion suggested to Bowra that the chorus may have been the guild of priestesses called Leucippides, who seem from a mysterious gloss in Hesychius to have been known as It is true that the comparison of girls with fillies is common enough in Greek, but the appearance of Helen as of girls like at Ar. Lys. 1308–15 seems, as Bowra says, ‘to hide a ritual use of ’. The existence of this guild of priestesses (...) appears to be established from Paus. 3. 16. 1 and 3. 13. 7. In the latter passage they join with the in offering sacrifice to Dionysus and the unnamed hero who first guided him to Sparta, but it seems reasonable to assume that their principal concern was with the cult of the goddesses Phoebe and Hilaeira, the daughters of Leucippus, from whom, as Pausanias explicitly says, they took their name. (shrink)

This article provides a critical comparative analysis of the substantive and procedural values and ethical concepts articulated in guidelines for allocating scarce resources in the COVID-19 pandemic. We identified 21 local and national guidelines written in English, Spanish, German and French; applicable to specific and identifiable jurisdictions; and providing guidance to clinicians for decision making when allocating critical care resources during the COVID-19 pandemic. US guidelines were not included, as these had recently been reviewed elsewhere. Information was extracted from each (...) guideline on: 1) the development process; 2) the presence and nature of ethical, medical and social criteria for allocating critical care resources; and 3) the membership of and decision-making procedure of any triage committees. Results of our analysis show the majority appealed primarily to consequentialist reasoning in making allocation decisions, tempered by a largely pluralistic approach to other substantive and procedural values and ethical concepts. Medical and social criteria included medical need, co-morbidities, prognosis, age, disability and other factors, with a focus on seemingly objective medical criteria. There was little or no guidance on how to reconcile competing criteria, and little attention to internal contradictions within individual guidelines. Our analysis reveals the challenges in developing sound ethical guidance for allocating scarce medical resources, highlighting problems in operationalising ethical concepts and principles, divergence between guidelines, unresolved contradictions within the same guideline, and use of naïve objectivism in employing widely used medical criteria for allocating ICU resources. (shrink)